1. Diferencias globales

1.1. Fracciones celulares

1.2. Nº genes diferencialmente expresados por cluster

2. Análisis diferencial por supercluster

2.1. B cells

a) Proporciones celulares

b) DGE: nº genes DE por cluster y top genes DE

## [1] "B cells (Fo)"

## [1] "B cells (PC-IgG2bc)"

## [1] "B cells (ME)"

## [1] "B cells (PC-IgG1)"

## [1] "B cells (PC-IgM)"

## [1] "B cells (PB-IgA)"

c) GSEA: top GO terms (BP)

## [1] "B cells (Fo)"

## [1] "B cells (PC-IgG2bc)"

## [1] "B cells (Prolif.)"

## [1] "B cells (PB-IgA)"

d) Expresión de cadenas pesadas de Ig

2.2. T cells, ILC cells y NK

a) Proporciones celulares

b) DGE: nº genes DE por cluster y top genes DE

## [1] "T cells (CD8+ TC1)"

## [1] "ILC (ILC2)"

## [1] "T cells (CD8+ TC22)"

## [1] "T cells (CD4+ MEM)"

## [1] "T cells (CD4+ Tregs)"

c) GSEA: top GO terms (BP)

## [1] "T cells (Th2)"

## [1] "T cells (CD8+ TC1)"

## [1] "ILC (ILC2)"

## [1] "T cells (Naive)"

## [1] "T cells (CD8+ TC22)"

## [1] "T cells (CD4+ MEM)"

## [1] "NK"

## [1] "T cells (CD4+ Tregs)"

## [1] "T cells (CD4+ Fol.h)"

## [1] "T cells (DN2)"

2.3. Myeloid cells y Granulocitos

a) Proporciones celulares

b) DGE: nº genes DE por cluster y top genes DE

## [1] "Macrophages"

## [1] "DC (cDC)"

## [1] "Neutrophils"

## [1] "DC (pDC)"

c) GSEA: to GO terms (BP)

## [1] "Macrophages"

## [1] "DC (cDC)"

## [1] "DC (pDC)"

## [1] "DC (cDC1)"

3. Rutas específicas seleccionadas